References for The Age-Well Plan
INTRODUCTION
1 https://www.bmj.com/content/368/bmj.l6669
WEEK 1
1 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2734064
2 https://www.nhs.uk/common-health-questions/lifestyle/what-are-the-health-risks-of-smoking/
3 https://www.sevencountriesstudy.com/smoking-all-cause-mortality-and-long-term-survival/
4 https://www.frontiersin.org/articles/10.3389/fendo.2019.00266/full
5 https://www.mentalhealth.org.uk/statistics/mental-health-statistics-stress
6 https://ehp.niehs.nih.gov/doi/10.1289/EHP4595
7 https://www.mpg.de/12823232/polluted-air-shortens-the-lifespan-of-europeans-by-about-two-years
8 https://d2ouvy59p0dg6k.cloudfront.net/downloads/plastic_ingestion_web_spreads.pdf
9 https://www.cell.com/cell/fulltext/S0092-8674(13)00645-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867413006454%3Fshowall%3Dtrue
10 https://www.frontiersin.org/articles/10.3389/fendo.2018.00790/full
11 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316637/
12 https://www.ncbi.nlm.nih.gov/pubmed/26059361
13 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582124/
14 https://www.ncbi.nlm.nih.gov/pubmed/23198888
WEEK 2
1 https://digital.nhs.uk/data-and-information/publications/statistical/statistics-on-obesity-physical-activity-and-diet/statistics-on-obesity-physical-activity-and-diet-england-2019/part-3-adult-obesity
2 https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30053-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413116300535%3Fshowall%3Dtrue
3 https://onlinelibrary.wiley.com/doi/10.1002/oby.22831
4 https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30248-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413119302487%3Fshowall%3Dtrue
5 https://www.bmj.com/content/365/bmj.l1451; https://www.bmj.com/content/365/bmj.l1949; https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2757497?guestAccessKey=0dd02341-f701-48a5-8d97-18b1173f7d9d&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121619
6 https://www.ncbi.nlm.nih.gov/pubmed/27810402
7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247583/
8 https://www.bmj.com/content/349/bmj.g6674
9 https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/mediterranean-diet-and-mortality-in-the-elderly-a-prospective-cohort-study-and-a-metaanalysis/F2D6B083AA187849477112DB77820521
10 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2717565
11 https://www.sciencedirect.com/science/article/abs/pii/S1053811918321517?via%3Dihub
12 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254277/?report=reader
13 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808895/#__ffn_sectitle
14 https://www.ncbi.nlm.nih.gov/pubmed/23079287
15 https://www.biorxiv.org/content/10.1101/507780v1.full
16 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192974/
17 https://link.springer.com/article/10.1007/s00394-019-02152-9
18 https://www.ncbi.nlm.nih.gov/pubmed/?term=green+tea+european+journal+of+cardiology
19 https://www.ncbi.nlm.nih.gov/pubmed/?term=olive+oil+Domenico+Praticò+autophagy
20 https://www.actascientific.com/ASNH/pdf/ASNH-02-0083.pdf
21 https://www.sciencedirect.com/science/article/abs/pii/S1053811918321517?via%3Dihub
22 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781043/#bib1
23 https://www.ncbi.nlm.nih.gov/pubmed/15681626
24 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910132/
25 https://www.ahajournals.org/doi/10.1161/JAHA.119.013543
26 https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.119.315506
27 https://www.ncbi.nlm.nih.gov/pubmed/21540874
28 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566462/
29 https://www.gastrojournal.org/article/S0016-5085(19)41244-4/fulltext
30 https://www.sciencedirect.com/science/article/pii/S002839081930139X?via%3Dihub
31 https://www.sciencedirect.com/science/article/abs/pii/S0939475319301474
WEEK 3
1 https://www.tandfonline.com/doi/full/10.1080/23723556.2019.1632613
2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546536/
3 https://www.bmj.com/content/365/bmj.l2323
4 https://www.bmj.com/content/366/bmj.l4570
5 https://www.dovepress.com/replacing-sedentary-time-with-physical-activity-a-15-year-follow-up-of-peer-reviewed-article-CLEP
6 https://academic.oup.com/aje/article/185/3/172/2915786
7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197470/
8 https://jamanetwork.com/journals/jamaneurology/article-abstract/2738357
9 https://www.mayoclinicproceedings.org/article/S0025-6196(19)30522-1/fulltext
10 https://ijbnpa.biomedcentral.com/articles/10.1186/s12966-019-0789-2
11 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528037/
12 https://ebm.bmj.com/content/21/3/109.long
13 https://bjsm.bmj.com/content/52/12/761
14 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025014/
15 https://www.ncbi.nlm.nih.gov/pubmed/30746447
16 https://onlinelibrary.wiley.com/doi/abs/10.1111/sms.13336
17 https://content.iospress.com/articles/brain-plasticity/bpl190093
18 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2130724
WEEK 4
1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628550/
2 https://academic.oup.com/sleep/article/39/3/653/2454026
3 https://www.intechopen.com/online-first/epigenetic-modulation-of-circadian-rhythms-bmal1-gene-regulation
4 https://www.nature.com/articles/s41593-019-0514-0
5 https://www.cell.com/current-biology/fulltext/S0960-9822(19)31368-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0960982219313685%3Fshowall%3Dtrue
6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394901/
7 https://www.ncbi.nlm.nih.gov/pubmed/21105176
8 https://www.ncbi.nlm.nih.gov/pubmed/27448477
9 http://www.themindlab.org
10 https://www.frontiersin.org/articles/10.3389/fpubh.2015.00233/full
11 https://www.bmj.com/content/349/bmj.g5312
12 https://www.eurekalert.org/pub_releases/2019-03/acoc-ana030519.php
13 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389641/
14 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222394
15 https://www.ncbi.nlm.nih.gov/pubmed/30374942
16 https://www.ncbi.nlm.nih.gov/pubmed/29312136
17 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2110998
WEEK 5
1 Mental Health Foundation, 2016
2 https://www.ageuk.org.uk/globalassets/age-uk/documents/reports-and-publications/reports-and-briefings/loneliness/loneliness-report.pdf
3 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186413
4 https://www.ncbi.nlm.nih.gov/pubmed/32025733
5 https://www.nature.com/articles/tp201581
6 https://journals.sagepub.com/doi/full/10.1177/0956797618763097
7 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191004
8 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580149/
9 https://journals.sagepub.com/doi/abs/10.1111/1467-9280.14461source
10 https://www.pnas.org/content/110/33/13684.full
11 https://www.ncbi.nlm.nih.gov/pubmed/26811548
12 https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1000316
13 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492806/
14 https://www.ageing.ox.ac.uk/blog/friendship-successful-ageing
15 https://onlinelibrary.wiley.com/doi/abs/10.1111/pere.12187
16 https://academic.oup.com/ageing/article/47/6/860/5073293
17 https://www.sciencedirect.com/science/article/abs/pii/S0306453014000584
18 https://content.iospress.com/articles/journal-of-alzheimers-disease/jad180164
19 https://www.sciencedirect.com/science/article/abs/pii/S0277953616303689
20 https://psycnet.apa.org/record/2014-28833-001
21 http://spp.sagepub.com/content/5/4/437.abstract
22 https://www.aarp.org/content/dam/aarp/health/brain_health/2017/07/gcbh-cognitively-stimulating-activities-report-english-aarp.doi.10.26419%252Fpia.00001.001.pdf
23 https://greatergood.berkeley.edu/images/application_uploads/Emmons-CountingBlessings.pdf
24 https://ggia.berkeley.edu/practice/three-good-things
25 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189134
26 https://www.hindawi.com/journals/jger/2015/954027/
27 https://content.iospress.com/articles/journal-of-alzheimers-disease/jad180571
28 https://www.pnas.org/content/116/37/18357
29 https://www.frontiersin.org/articles/10.3389/fnhum.2017.00599/full
WEEK 6
1 https://journal.chestnet.org/article/S0012-3692(18)32723-5/fulltext
2 https://www.ncbi.nlm.nih.gov/pubmed/32302812
3 https://pubs.acs.org/doi/abs/10.1021/acs.est.8b07141#
4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946571/
5 https://ehjournal.biomedcentral.com/articles/10.1186/s12940-020-0565-4
6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707925/
7 https://www.nrdc.org/resources/not-just-dirt-toxic-chemicals-indoor-dust
8 https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2757789
9 https://advances.sciencemag.org/content/3/7/e1700782
10 https://pubs.acs.org/doi/abs/10.1021/acs.est.9b01517
11 https://www.mdpi.com/2304-8158/9/1/72/htm
12 https://www.sciencedirect.com/science/article/pii/S0048969719320832
13 http://www.euro.who.int/__data/assets/pdf_file/0008/383921/noise-guidelines-eng.pdf?ua=1
14 https://academic.oup.com/eurheartj/article/38/29/2290/3858093
15 https://www.ncbi.nlm.nih.gov/pubmed/29518662
16 https://academic.oup.com/heapro/article/35/1/50/5252008
17 https://www.frontiersin.org/articles/10.3389/fpsyg.2019.00722/full
18 https://www.sciencedirect.com/science/article/abs/pii/S1352231015001193?via%3Dihub
19 https://www.ncbi.nlm.nih.gov/pubmed/29716592
20 https://ehp.niehs.nih.gov/doi/full/10.1289/ehp.8700?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
21 https://www.thoracic.org/about/newsroom/press-releases/resources/women-cleaners-lung-function.pdf
22 https://www.sciencedirect.com/science/article/pii/S0048969719312525
23 https://www.jdsjournal.com/article/S0923-1811(16)30816-7/fulltext
24 https://www.jdsjournal.com/article/S0923-1811(16)30816-7/fulltext
25 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824304/
26 https://ntrs.nasa.gov/archive/nasa/casi.ntrs.nasa.gov/19930073077.pdf
27 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419447/
28 https://www.who.int/ageing/publications/Global_age_friendly_cities_Guide_English.pdf
29 https://www.sciencedirect.com/science/article/pii/S0277953619303284?via%3Dihub
References for The Age-Well Project
INTRODUCTION
1 http://epublications.uef.fi/pub/urn_isbn_978-952-61-1394-4/urn_isbn_978-952-61-1394-4.pdf
2 https://drmalcolmkendrick.org/2019/01/02/what-causes-heart-disease-part-60-prediction/
3 https://www.nhs.uk/News/Pages/NewsArticles.aspx?TopicId=&Page=3
4 Blue Zoners refer to the ƒ First Cornerstone. Read more at ww.bluezones.com. superagers refers to a group of elderly people with the cognitive abilities of much younger people, studied in research projects like ‘The 90+ Study’ from the US Clinic for Aging Research and Education (CARE).
5 https://www.nejm.org/doi/full/10.1056/NEJMoa1800389
6 https://www.ncbi.nlm.nih.gov/pubmed/23670794/
7 https://www.ncbi.nlm.nih.gov/pubmed/26365989
8 https://www.ncbi.nlm.nih.gov/pubmed/29029009
9 https://www.ncbi.nlm.nih.gov/pubmed/28714795
10 https://www.ncbi.nlm.nih.gov/pubmed/29143320
11 https://www.webmd.com/special-reports/anti-aging-science/20170404/super-ager-secrets
12 http://www.jneurosci.org/content/36/37/9659
13 Feldman Barrett, quoted in The Guardian, April 2017
14 https://alumni.berkeley.edu/california-magazine/just-in/2015-06-02/lack-sleep-may-lead-dementia-new-research-finds-it-makes
15 https://www.scripps.edu/news-and-events/press-room/2016/20161110puthanveettil.html
16 Flinders University, Adelaide, published in Sleep Medicine Reviews, Nov. 2018
17 https://www.ahajournals.org/doi/10.1161/JAHA.118.008552
18 National Cancer Research Institute, ‘Women who are ‘larks’ have a lower risk of developing breast cancer: Analyses of genetic variants show the effect of sleep on breast cancer risk.’5 November 2018.
CHAPTER 1
1 Although they can also be triggered by exposure to environmental toxins or radiation, for example.
2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761710/
3 Vidacek NS et al Telomeres, Nutrition and Longevity. J Gerontol A Biol Sci Med Sci2017; Freitas-Simoes TM et al, Nutrients, Foods dietary patterns and telomere length. Metabolism2016. Rafie N et al Dietary Patterns, food groups and telomere length: a systematic review. Eur J Clin Nutr. 2017
4 Gokarn R et al The Relationship between Dieetary Mancronutrients and Telomere length in Aging Mice. J Gerontol A Biol Sci Med Sci 2018.
5 Blackburn E & Epel E, The Telomere Effect, 2017. Unless otherwise footnoted, most of the studies cited here are sourced from here.
6 Lavretsky H et al. A pilot study of yogic meditation for family dementia caregivers. Int J Geriatr Psychiatry2013
7 Schutte NS et al A meta-analytic review of the effects of mindfulness meditation on telomerase activity. Psychoneuroendocrinology2014
8 A survey of 4000 women found that drinking caffeinated coffee resulted in longer telomeres.
9 Vera E et al. Telomerase Reverse Transcriptase Synergizes with Calorie Restriction to Increase Health Span and Extend Mouse Longevity.PLoS ONE, 2013
10 Telomeres respond well to optimism, purpose and positivity. Several studies have found that conscientiouspeople (defined as organised, persistent, purposeful and task-oriented) live longer, but new research shows they also have longer telomeres.
11 Telomeres seem to like 30-minute chunks of moderate or vigorous exercise, or HIIT five days a week! Obese women have been found to have shorter telomeres than thin women, and regular exercisers have been found to have longer telomeres than those with sedentary lives.
12 Older people in particular benefit from more sleep and those that achieve it appear to have longer telomeres.
13 Telomeres appear to be ‘creatures’ of habit and Blackburn and Epel suggest going to bed and getting up at the same time every day may be critical to our cells’ ability to regulate telomerase.
14 Seven pesticides – so far – have been linked to significantly shorter telomeres. Fortunately, most of these are banned or severely restricted in the European Union at the time of writing.
15 PAHs are found in traffic pollution and flame-grilled meat – which have been linked to shorter telomeres in cases of high exposure.
16 All of these are associated with longer telomeres according to Blackburn and Epel
17 Tim Spector, The Diet Myth
18 Burford, Microbiome Journal, July 2017
19 https://www.tandfonline.com/doi/full/10.1080/19490976.2018.1494102
20 Zuscik M et al, JCI Insight. 2018
21 Knight R et al, First Findings of the American Gut Project, mSystems, 2018
22 https://edition.cnn.com/2014/06/18/health/good-gut-bacteria/index.html
23 https://www.ncbi.nlm.nih.gov/pubmed/28899766
24 https://www.nejm.org/doi/full/10.1056/NEJMoa1707914
25 https://link.springer.com/article/10.1007 per cent2Fs10522-010-9292-5
26 https://www.physiology.org/doi/10.1152/ajpendo.00319.2002
27 http://www.nature.com/articles/nature08780
28 https://www.sciencedirect.com/science/article/pii/S0960982216303384
30 Kivipelto M et al. Obesity and vascular risk factors at midlife and the risk of dementia. Arch Neurol 2005
31 Lean M & Thom G, Is there an optimal diet for weight management and metabolic health? Gastroenterology 2017
32 Fontana L et al. Optimal body weight for health and longevity. Aging Cell. 2014
33 The relationship between adiposity and cognitive function in a large community-dwelling population: data from the Trinity Ulster Department of Agriculture (TUDA) ageing cohort study.British Journal of Nutrition, 2018; 1 DOI: 10.1017/S0007114518001848
34 https://www.ncbi.nlm.nih.gov/pubmed/21461943
35 https://www.theguardian.com/society/2018/feb/19/scientists-unravel-secrets-of-superagers
36 http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2004399
37 European Heart Journal, 2018; DOI: 10.1093/eurheartj/ehy288
38 Stamler J. et al. Hypertension, March 2018
39 Juraschek S et al, Journal of the American College of Cardiology, Nov 2017
40 Wilck N et al, Nature, Nov 2017
41 Silva-Cutini et al. https://www.fasebj.org/doi/10.1096/fasebj.2018.32.1_supplement.924.2
42 https://hms.harvard.edu/news/relax-repeat
43 Study findings presented at British Science Assoc 2018 convention, Hull.
44 Feelisch M. et al. Journal Investigative Dermatology2014, found that nitric oxide stored in the top layers of the skinreacts to sunlight, causing bloodvessels to widen as the oxide moves into the bloodstream, and thus lowering blood pressure
45 https://www.diabetes.co.uk/diabetes-prevalence.html
46 Brain Food, Dr Lisa Mosconi
47 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809120/
48 https://link.springer.com/article/10.1007/s00125-017-4541-7
49 https://www.diabetes.co.uk/causes-of-type2-diabetes.html
50 https://www.ncbi.nlm.nih.gov/pubmed/24300018
51 30 Kivipelto M et al. Obesity and vascular risk factors at midlife and the risk of dementia. Arch Neurol 2005
52 https://www.nature.com/articles/srep46642
53 https://esc365.escardio.org/Congress/ESC-Congress-2018/HDL-cholesterol-A-moving-target/174943-elevated-hdl-c-is-associated-with-adverse-cardiovascular-outcomes
54 https://www.ncbi.nlm.nih.gov/pubmed/23021013
55 https://onlinelibrary.wiley.com/doi/full/10.1002/ptr.5805
56 www.ncbi.nlm.nih.gov/pubmed/16011467and 15741046
57 Savignac H et al. Prebiotic feeding elevates central BDNF. Neurochemistry Int. 2013
58 www.ncbi.nlm.nih.gov/pubmed/16011467and 15741046
59 www.ncbi.nlm.nih.gov/pubmed/12088740
60 https://osteopathic.org/2017/05/01/widespread-vitamin-d-deficiency-likely-due-to-sunscreen-use-increase-of-chronic-diseases/
61 www.ncbi.nlm.nih.gov/pmc/articles/PMC3487856/and www.ncbi.nlm.nih.gov/pubmed/25138265
62 Schmitt K et al, Annals of Medicine 2016
63 Cahn B et al, Frontiers in Human Neuroscience, Aug. 2017
64 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC534658/
65 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040186
66 http://journals.sagepub.com/doi/10.1177/2047487318777387
67 https://www.sciencedirect.com/science/article/pii/S0091743516303991?via per cent3Dihu
68 http://emboj.embopress.org/content/34/12/1674
69 http://n.neurology.org/content/early/2018/10/24/WNL.0000000000006549
70<note?>
71 The Nature Fix, Florence Williams, 2017
72 http://www.pnas.org/content/113/33/9327
73 https://www.biologicalpsychiatryjournal.com/article/S0006-3223(16)32582-3/fulltext
74 https://thebms.org.uk/2017/03/new-paper-professor-robert-d-langer-demonstrates-whi-study-errors-led-15-years-unnecessary-suffering-women/
75 https://www.ncbi.nlm.nih.gov/pubmed/28202700
76 https://www.ncbi.nlm.nih.gov/pubmed/28904736
CHAPTER 2
1 European Society of Human Genetics Conference, 15/06/2018
CORNERSTONE ONE INTRODUCTION
1 https://www.tctmd.com/news/redefined-high-quality-diet-lowers-risk-all-cause-mortality-pure
2 https://www.ncbi.nlm.nih.gov/pubmed/29263222
CHAPTER 3
1 Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories.Cell Metabolism, 2018
2 Interview, UEA, 2018
3 Harper D, Live Well to 101, Headline 2018XX
4 The Obesity Code, Dr Jason Fung
5 https://www.aviva.com/newsroom/news-releases/2016/12/uk-death-of-the-home-cooked-dinner-tea-time-becomes-takeaway-time-for-millennials-17705/
6 https://www.nature.com/articles/ncomms14063
7 https://nyulangone.org/press-releases/calorie-restricting-diets-slow-aging-study-finds
8 https://www.cell.com/cell-reports/fulltext/S2211-1247(15)00505-7
9 https://academic.oup.com/jn/article-abstract/148/4/624/4965931
10 https://www.sciencedirect.com/science/article/pii/S0735109717375216?via per cent3Dihub
11 http://circ.ahajournals.org/content/early/2018/04/25/CIRCULATIONAHA.117.032047
12 Baranski MC et al, British Journal Nutrition, 2014
13 Benbrook C et al, Enhancing the fatty acid profile of milk through forage-based rations, with nutrition modeling of diet outcomes. Food Science & Nutrition, 2018
14 PAN, Pesticides on a Plate, 2013
15 http://online.liebertpub.com/doi/10.1089/rej.2014.1624
16 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990190/
17 http://www.translationalres.com/article/S1931-5244(14)00200-X/fulltext
18 https://www.ncbi.nlm.nih.gov/pubmed/29238290
19 https://www.ncbi.nlm.nih.gov/pubmed/24048020
20 https://www.ncbi.nlm.nih.gov/pubmed/17490982
21 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452241/
22 https://academic.oup.com/biomedgerontology/article/71/10/1335/2198172
23 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32252-3/abstract
24 http://science.sciencemag.org/content/362/6416/764
25 https://jamanetwork.com/journals/jamacardiology/fullarticle/2618359
26 All research cited on http://www.worldactiononsalt.com/salthealth/olderpopulation/index.html
27 H. Zhu et al. Dietary Sodium, Adiposity, and Inflammation in Healthy Adolescents.PEDIATRICS, 2014; DOI: 10.1542/peds.2013-1794
28 Andrew Mente et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies.The Lancet, 2016
29 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)31376-X/fulltext
30 http://www.bmj.com/content/360/bmj.k322
31 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2087877
32 https://gut.bmj.com/content/early/2018/03/08/gutjnl-2017-314786
33 https://academic.oup.com/jn/article-abstract/148/9/1434/5054990?redirectedFrom=fulltext
34 https://academic.oup.com/ajcn/article-abstract/108/5/971/5106980?redirectedFrom=fulltext
35 https://www.ncbi.nlm.nih.gov/pubmed/29662231
36 https://www.ncbi.nlm.nih.gov/pubmed/29274927
37 wcrf.org/colorectal-cancer-2017
38 http://circheartfailure.ahajournals.org/content/early/2014/06/11/CIRCHEARTFAILURE.113.000921
39 https://www.ncbi.nlm.nih.gov/pubmed/25838035
40 https://www.ncbi.nlm.nih.gov/pubmed/28420091
41 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342583/
42 The Diet Myth, Tim Spector
43 https://www.ncbi.nlm.nih.gov/pubmed/27491070
44 https://content.iospress.com/articles/journal-of-alzheimers-disease/jad140720
45 https://academic.oup.com/jcem/article/94/11/4483/2596935
46 https://link.springer.com/article/10.1007 per cent2Fs00125-016-4053-x
47 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769029/
48 https://www.tandfonline.com/doi/abs/10.1080/19440049.2015.1010607
CHAPTER 4
1 Akbari E. et al Frontiers in Aging Neuroscience, Nov 2016
2 Yadav H. et al, Frontiers in Nutrition, Apr 2018
3 Cardona F. et al, Benefits of Polyphenols on Gut Microbiota, Journal Nutr. Biochem. 2013
4 Voigt R et al, Circadian Disorganisation Alters Intestinal Microbiome, PLOS One 2014
5 Pederon et al, GenomeMagazine, 2016
6 http://www.pressat.co.uk/releases/new-ucl-research-is-your-probiotic-dead-or-alive-aec1a08b3e281474e1ac000430862fc5/
7 Walnut Consumption Alters the Gastrointestinal Microbiota, Microbially Derived Secondary Bile Acids, and Health Markers in Healthy Adults: A Randomized Controlled Trial.The Journal of Nutrition, 2018
8 Valdes and Menni. Omega-3 intake linked to greater microbiome diversity. Naturescientific report 2017
9 Flemish Gut Flora Project, ScienceMagazine 2016
10 Zheng et al. Metabolomics Investigation to Shed Light on Cheese as a Possible Piece in French Paradox Puzzle, Journal of Agriculture and Food Chemistry2015
11 Longo V et al. Fasting: Molecular Mechanisms and Clinical Applications, Cell Metabolism 2014
12 Studies quoted in the Clever Guts Dietby Dr Michael Mosley
13 Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling. Cell Metabolism, 2015
14 Allen et al. Exercise Alters Gut Microbiota Composition. Med Sci Sports Exerc2018
15 Rosselot et al.Rhythm and bugs: Circadian clocks, gut microbiota, and enteric infections. Curr Opin Gastroenterel 2016
CHAPTER 5
1 https://www.cdc.gov/pcd/issues/2014/13_0390.htm#table2_down
2 https://www.ncbi.nlm.nih.gov/pubmed/29263222
3 https://www.ncbi.nlm.nih.gov/pubmed/29628462
4 https://www.ncbi.nlm.nih.gov/pubmed/29618474
5 https://www.bmj.com/content/341/bmj.c4229
6 https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2480455
7 https://www.ncbi.nlm.nih.gov/pubmed/24253316
8 https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-a/
9 https://www.ncbi.nlm.nih.gov/pubmed/26287411
10 https://www.ncbi.nlm.nih.gov/pubmed/28464411
11 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082894/
12 https://www.ncbi.nlm.nih.gov/pubmed/29169723
13 https://www.ncbi.nlm.nih.gov/pubmed/29056888
14 https://www.ncbi.nlm.nih.gov/pubmed/28983192
15 https://www.ncbi.nlm.nih.gov/pubmed/22435414
16 https://www.bmj.com/content/363/bmj.k4067
17 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2530286
18 https://www.ncbi.nlm.nih.gov/pubmed/?term=Cristina+Menni+omega+3+microbiome
19 https://www.ncbi.nlm.nih.gov/pubmed/26052283
20 https://www.ncbi.nlm.nih.gov/pubmed/23010452
21 Harris WS. Omega-3 fatty acids. In: Coates PM, Betz JM, Blackman MR, et al., eds. Encyclopedia of Dietary Supplements. 2nd ed. London and New York: Informa Healthcare; 2010:577-86.
22 Interview, 2018
23 https://www.ncbi.nlm.nih.gov/pubmed/10852422
24 https://www.ncbi.nlm.nih.gov/pubmed/30019399
25 https://jamanetwork.com/journals/jama/fullarticle/2484683
26 http://www.telegraph.co.uk/news/health/news/11095351/Farmed-salmon-has-more-fat-than-pizza.html
27 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713359/
28 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713300/
29 https://www.researchgate.net/profile/Guadalupe_Loarca-Pina/publication/312274386_Minor_components_of_pulses_and_their_potential_impact_on_human_health/links/5879152408ae9a860fe2c1b7/Minor-components-of-pulses-and-their-potential-impact-on-human-health.pdf
30 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555112/
31 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1384247
32 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016088/
33 http://www.clinicalnutritionjournal.com/article/S0261-5614(17)31439-5/abstract
34 Bertram H, Journal of Agriculture & Food Chemistry, 2015
35 https://www.ncbi.nlm.nih.gov/pubmed/27531646
36 https://www.ncbi.nlm.nih.gov/pubmed/27241245
37 Buettner D. The Blue Zones: 9 Lessons for Living Longer from the People Who’ve Lived the Longest 2012
38 Liu L. Cancer Research, 2017
39 Berk L et al, FASEB Journal, 2018.
40 Berk L et al, FASEB Journal, 2018; Latif R, Neth Journal Med, 2013; Socci V et al, Front Nutr. 2017;
41 Socci & Ferrara, University of L’Aquila
42 Based on USDA analysis 2013
43 Liu et al. Spermidine prolongs lifespan and prevents liver fibrosis and hepatocellular carcinoma by activating MAP1S-mediated autophagy. Cancer Research, 2017
44 De Cabo & Navas, Nature Mag, 2016
45 Ibid
46 Soda K et al. J Nutr Sci. 2009
47 Eisenberg T et al, Nat Med 2016
48 The American Journal of Clinical Nutrition, Volume 108, Issue 2, 1 August 2018
49 Journal Biochemistry, Vol. 139, 2006
50 The free-radical theory of ageing says ageing is caused when cells accumulate free-radical damage. Free radicals are highly reactive molecules with a single unpaired electron in an outer shell that can damage healthy cells. Antioxidants are thought to counter them
51 Wolk A et al, American Journal Medicine 2012
52 Greger M, How Not to Die, 2016
53 Greger M., How Not to Die, 2018
54 Rehen S, Advances in Regenerative Biology 2015
55West S et al, Nutrition Today, 2014
56 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827376/
57 https://www.ncbi.nlm.nih.gov/pubmed/19678780
58 https://www.ncbi.nlm.nih.gov/pubmed/27561811
59 https://www.ncbi.nlm.nih.gov/pubmed/27261998
60 https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.6b00975
61 https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-016-0730-3
62 http://www.onlinejacc.org/content/70/20/2519?sso=1&sso_redirect_count=1&access_token=
63 https://academic.oup.com/ajcn/article/102/6/1347/4555173
64 https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.636.24
65 https://www.ncbi.nlm.nih.gov/pubmed/24898229
66 https://www.nejm.org/doi/full/10.1056/nejmoa1200303
67 https://www.ncbi.nlm.nih.gov/pubmed/15383514
68 https://www.ncbi.nlm.nih.gov/pubmed/10737284
69 https://www.ncbi.nlm.nih.gov/pubmed/15642702
70 https://www.ncbi.nlm.nih.gov/pubmed/19887798
71 https://www.ncbi.nlm.nih.gov/pubmed/28894509
72 https://www.ncbi.nlm.nih.gov/pubmed/24975408
73 https://link.springer.com/article/10.1007/s11745-009-3306-6
74 https://www.ahajournals.org/doi/abs/10.1161/CIR.0000000000000510
75 https://www.researchgate.net/publication/324805491_Ketogenic_diet_enhances_neurovascular_function_with_altered_gut_microbiome_in_young_healthy_mice
76 https://www.ncbi.nlm.nih.gov/pubmed/29914035
77 https://www.ncbi.nlm.nih.gov/pubmed/23892389
78 https://www.ncbi.nlm.nih.gov/pubmed/24328700
79 https://www.ncbi.nlm.nih.gov/pubmed/23024690
80 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855206/
81 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053258/
82 https://academic.oup.com/cdn/article/1/12/cdn.117.001289/4772172
83 https://www.ncbi.nlm.nih.gov/pubmed/27881394
84 http://www.who.int/features/qa/cancer-red-meat/en/
85 https://www.ncbi.nlm.nih.gov/pubmed/29210053
86 https://www.ncbi.nlm.nih.gov/pubmed/28397016
87 https://www.journal-of-hepatology.eu/article/S0168-8278(18)30058-8/fulltext
88 http://josephpoore.com/Science per cent20360 per cent206392 per cent20987 per cent20- per cent20Accepted per cent20Manuscript.pdf
89 https://www.ncbi.nlm.nih.gov/pubmed/29954759
90 https://pubs.acs.org/doi/full/10.1021/jf2036033
91 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ana.23594
92https://www.ncbi.nlm.nih.gov/pubmed/20047325/
93 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971226/
94https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804301/
95 http://www.blueberrystudy.org/home
96 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.112.122408
97 https://www.ncbi.nlm.nih.gov/pubmed/24336456
98 https://www.nature.com/articles/s41598-018-22388-5
99 https://www.sciencedirect.com/science/article/pii/S030881461730691X?via per cent3Dihub
100 https://www.ncbi.nlm.nih.gov/pubmed/20567593
101 https://www.ncbi.nlm.nih.gov/pubmed/24257554
102 https://www.ncbi.nlm.nih.gov/pubmed/26475179
103 https://www.sciencedirect.com/science/article/pii/S1756464618301476?via=ihub#!
CHAPTER 6
1 Nutrients.2012 Jul;4(7):759-81
2 Nutrients.2012 Jul;4(7):759-81
3 Nutr Metab Cardiovasc Dis.2016 Jun;26(6):443-67
4 Costanzo et al, European Journal Epidemiology 2011
5 Clin J Am Soc Nephrol.2013 Aug;8(8):1389-95
6 Nutr Hosp.2015 Jul 18;32 Suppl 1:32-4
7 https://www.sciencedaily.com/releases/2010/02/100208091922.htm
8 https://beer-and-health.co.uk/nutritional-information/
9 Behav Brain Res.2014 Dec 15;275:1-10
10 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30134-X/fulltext#seccestitle120
11 https://www.medpagetoday.com/primarycare/dietnutrition/18347
12 Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism.
Burgos-Barragan G, Wit N, Meiser J, Dingler FA, Pietzke M, Mulderrig L, Pontel LB, Rosado IV, Brewer TF, Cordell RL, Monks PS, Chang CJ, Vazquez A, PatelKJ.
Nature. 2017 Aug 31;548(7669):549-554
13 BMJ2004;329:539
14 https://medium.com/@UCIrvine/claudia-kawas-90-study-moderate-alcohol-and-coffee-consumption-may-improve-longevity-119e0cfd8ce0
15 R. Corder, The Wine Diet, 2011
16 Moderate alcoholconsumption and cognitive risk. Neafsey EJ,Collins MA.Neuropsychiatr Dis Treat.2011;7:465-84
17Alcohol consumption and risk of dementia: 23 year follow-up of Whitehall II cohort study. BMJ, 2018;
18 https://www.eurekalert.org/pub_releases/2008-12/cu-alw120408.php
19 https://www.hopkinsmedicine.org/news/media/releases/How_Red_Wine_May_Shield_Brain_From_Stroke_Damage
20 https://cancerci.biomedcentral.com/articles/10.1186/1475-2867-14-6 per cent20
21 https://jamanetwork.com/journals/jama/fullarticle/203337
22 http://www.fasebj.org/doi/10.1096/fj.201700400RR
23 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363808/pdf/84-6691691a.pdf
24 https://www.futuremedicine.com/doi/10.2217/nnm.12.83
25 https://pubs.acs.org/doi/abs/10.1021/jacs.7b05012
26 http://journals.sagepub.com/doi/10.1097/HJR.0b013e3282f4832f
27 http://www.pnas.org/content/105/38/14692.short
28 http://www.aicr.org/enews/2018/05-may/enews-coffee-and-your-cancer-risk.html
29 Report from Southampton University published BMJ Nov 2017
30 Report from University of Navarra, reported in European Society of Cardiology Newsletter, Aug 2017
31 https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2686145
32 http://www.mind.uci.edu/research-studies/90plus-study/
33 Report from Stanford University, reported in Nature Magazine 2017
34 Ross S. Mancini, Yanfei Wang, Donald F. Weaver. Phenylindanes in Brewed Coffee Inhibit Amyloid-Beta and Tau Aggregation. Frontiers in Neuroscience, 2018
35 Food Chem. 2012 Oct 15;134(4):1870-7.
36 https://www.ncbi.nlm.nih.gov/pubmed/11528342
37 https://www.ncbi.nlm.nih.gov/pubmed/?term=Farrell per cent2C+Egan+Denton+water+consumption+2007
38 https://academic.oup.com/sleep/advance-article-abstract/doi/10.1093/sleep/zsy210/5155420?redirectedFrom=fulltext
39 https://insights.ovid.com/crossref?an=00005768-201811000-00021
CORNERSTONE TWO INTRODUCTION
1 https://www.ahajournals.org/doi/10.1161/JAHA.117.007678
CHAPTER 7
1 Buckley JP, et al. Br J Sports Med 2015;0:1–6. doi:10.1136/bjsports-2015-094618
2 All-cause mortality attributable to sitting time, Leandro Rezende et al., American Journal of Preventive Medicine, published online 23 March 2016.
3 Study from Birmingham University presented to British Science Association annual conference, 2018
4 Dr. Loretta DiPietro, published in the Journal of Gerontology: Medical Sciences Aug 2017
5 University of California – Los Angeles. ‘Sitting is bad for your brain — not just your metabolism or heart: Thinning in brain regions important for memory linked to sedentary habits.’ ScienceDaily. ScienceDaily, 12 April 2018.
6 https://www.leeds.ac.uk/news/article/3758/if_youre_sitting_down_dont_sit_still_new_research_suggests
7 https://www.ncbi.nlm.nih.gov/pubmed/29127602. Also:Fiattarone MA, Marks EC et al HIIT in nonagenarians: effects on skeletal muscle. JAMA 1990. Verney J et al Combined Lower Body Enddurnace and upper body resistance training improves performance and health parametres in healthy active elderly. Eur J Appl Physiol. 2006
8 Matthew M. Robinson et al. Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans.Cell Metabolism, 2017. DOI: 10.1016/j.cmet.2017.02.009
9 Jennifer J. Heisz et al. The Effects of Physical Exercise and Cognitive Training on Memory and Neurotrophic Factors.Journal of Cognitive Neuroscience, 2017; 29 (11): 1895 DOI
10 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0154075
11 American Journal of Preventative Medicine, Oct 2017
12 Panter J et al. Using alternatives to the car and risk of all-cause, cardiovascular and cancer mortality. Heart, 2018.
13 Kam L, presented at Experimental Biology, 2017
14 Hackett R et al, Walking Speed, Cognitive Function and Dementia Risk in the English Longitudinal Study of Ageing. Journal of the American Geriatrics Society, 2018
15 Merlo C, European Journal Preventive Cardiology, 2018
16 Pedro F et al, Moderate-to-Vigorous Physical Activity and All-Cause Mortality: Do Bouts Matter? Journal of American Heart Association, 2018
17 Bratman G et al,Proceedings of the National Academy of Sciences Jul 2015
18 Church T et al, Research Quarterly for Exercise & Sport, 2002
19 Roger Ulrich. Published in American Assoc. for Advancement Science 1984
20 All Japanese research from Environ Health Prev Med 2010, review of Shirin-yoku research. Tsunetsgsugo, Park, Miyazaki.
21 Dr Quing Li, Shinrin-yoku: The Art and Science of Forest Bathing, 2018
22 Arnsten, 2009; Hajszan, et al., 2009; Numan, 1978; Pruessner,et al., 2005
23 Berman, Jonides & Kaplan, The Cognitive Benefits of Interacting with Nature, published in Psychological Science 2008
24 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216244/
25 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808943/
26 https://nos.org.uk/about-osteoporosis/your-bone-strength/bone-building-exercise/
27 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000500514
28 https://www.ncbi.nlm.nih.gov/pubmed/24460005
29 Tomita M. et al. Journal Physical and Occupational Therapy in Geriatrics, 2018
30 https://news.utexas.edu/2004/10/19/nr_education
31 Kraschnewski J. et al. Is Strength Training Associated with Mortality? Journal Preventative Medicine 2016
32 Yanghui Liu et al. Associations of Resistance Exercise with Cardiovascular Disease Morbidity and Mortality.Medicine & Science in Sports & Exercise, 2018
33 https://www.news-medical.net/news/20170826/Dancing-has-profound-effect-in-reversing-signs-of-aging-in-the-brain.aspx
34 https://www.pmrjournal.org/article/S1934-1482(16)30189-7/fulltext
35 Journal of Physical Aging and Activity, Jan 2014
36 Bee & Schenker, The Ageless Body, 2015
37 P. Horn et al Physiol Res.2015;64(2):203-7. 2014
38 Quoted in Waitrose Mag, Spring 2018
39 http://www.alzheimersweekly.com/2015/09/ping-pong-alzheimers.html
40 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604064/
41 https://tabletennisengland.co.uk/news/archived/stay-young-with-help-from-table-tennis/
42 Quoted in https://www.mnn.com/health/fitness-well-being/blogs/ping-pong-good-for-brain
43 Quoted in http://www.weightwatchers.com/util/art/index_art.aspx?tabnum=4&art_id=167831
44 Foster C et al, British Journal Sports Medicine, 2016
45 http://www.drmccall.com/uploads/2/2/6/5/22658464/101healthconditionshelpedbyyoga.pdf
46 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442161/
47 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278216/
48 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097916/
49 https://www.frontiersin.org/articles/10.3389/fimmu.2017.00670/full
50 https://www.ncbi.nlm.nih.gov/pubmed/24657958
51 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149061/
52 https://www.liebertpub.com/doi/10.1089/acm.2016.0140
53 https://content.iospress.com/articles/journal-of-alzheimers-disease/jad150653
54 https://www.ncbi.nlm.nih.gov/pubmed/25824030
55 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788823/
56 https://www.bodyworkmovementtherapies.com/article/S1360-8592(14)00015-1/fulltext
CORNERSTONE THREE INTRODUCTION
1 the term coined to describe the 5 per cent of older population whose razor-sharp minds are on a par with people 30-40 years younger
2 http://www.mdmag.com/conference-coverage/aan-2018/quantifying-social-networks-and-cognition-in-neurology
3 https://www.ncbi.nlm.nih.gov/pubmed/30365023
4 https://heart.bmj.com/content/102/24/2016
CHAPTER 8
1 https://www.theguardian.com/society/2017/oct/12/loneliness-as-bad-for-health-as-long-term-illness-says-gps-chief
2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941164/
3 https://www.ncbi.nlm.nih.gov/pubmed/27091846
4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910600/
5 https://academic.oup.com/ppar/article/27/4/127/4782506
6 Susan Pinker, The Village Effect2015
7 Friedman & Martin, The Longevity Project, 2011
8 https://www.ncbi.nlm.nih.gov/pubmed/?term=hogg+hardill+2011
9 https://www.ncbi.nlm.nih.gov/pubmed/28958028
10 https://www.ncbi.nlm.nih.gov/pubmed/24769739
11 Sainsbury’s Living Well Index, May 2018
12 https://www.universityofcalifornia.edu/news/facebook-users-live-longer-study-says
13 Wendy Mitchell, Somebody I used to Know, Bloomsbury 2018
14 Blackburn & Epel, The Telomere Effect, 2017
15 Friedman and Martin, The Longevity Project 2011
16 https://www.health.harvard.edu/newsletter_article/marriage-and-mens-health
17 https://heart.bmj.com/content/early/2018/06/06/heartjnl-2018-313005
18 Journal Neurology, Neurosurgery and Psychiatry, 2017
19 http://feeds.bmj.com/jnnp/podcasts, Feb 2018
20 Waldinger R., TED talk. What Makes a Good Life
21 All studies cited in Levin et al. Faith, Medicine and Science, 2011
22 Ibid.
23 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177618
24 http://journals.sagepub.com/doi/full/10.1177/1948550618779820
25 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478470/
26 https://jech.bmj.com/content/70/9/917.short
27 https://www.ncbi.nlm.nih.gov/pubmed/17371091
28 https://www.ncbi.nlm.nih.gov/pubmed/17874946
29 Kuhn A et al, Institute for Empirical Research in Economics, Zuric, Working paper No. 499, 2010
30 Behncke S. Does Retirement Trigger Ill Health? Health Economics, Vol 21, Issue 3, 2012
31 Muller T & Shaikh M. Your Retirement and my Health Behaviour. Journal of Health Economics. Jan 2018
32 Zins et al, 2018
33 MacKenzie C. Melbourne Institute Worker Papers 2016
34 https://www.health.harvard.edu/staying-healthy/working-later-in-life-can-pay-off-in-more-than-just-income
35 http://jech.bmj.com/content/71/9/905
36 https://www.nature.com/articles/s41598-017-16118-6
37 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645535/
38 https://www.ncbi.nlm.nih.gov/pubmed/1435469?dopt=Abstract
39 https://www.nytimes.com/2017/06/06/well/family/are-pets-the-new-probiotic.html
40 http://rspb.royalsocietypublishing.org/content/282/1814/20151139
41 https://www.health.harvard.edu/staying-healthy/get-healthy-get-a-dog
CHAPTER 9
1 Langa KM. Is the risk of AD and dementia declining? Alzheimer’s Res Ther. 2015
2 BMC Geriatr.2018 Apr
3 Lavrencic L et al. Is there a link between cognitive reserve and cognitive function in the oldest-old? Journal Geron A Bio A Med 2018
4 Journal of Aging and Health, Sept 2012
5 Beaty R et al Robust prediction of individual creative ability from brain functional connectivity. Proceedings of the National Academy of Sciences, 2018
6 Chapman B et al, Journal Aging Research, 2011
7 Seattle Longitudinal Study, Schaie & Willis, 1999. Same findings in Edinburgh Artery Study 2009.
8 Buchalter S. Art Therapy and Creative Coping for Older Adults, 2011
9 Woolston C. Writing for Therapy helps erase effects of trauma. Communication, 2000
10 Interview, UEA, 2018
11 https://bluezones.com/2012/08/age-gracefully-by-maintaining-mental-vitality/
12 Bunseck and Düzel, Neuron, Cell Press 2006
13 https://bluezones.com/2012/08/age-gracefully-by-maintaining-mental-vitality/
14 Bavishi, Slade and Levy, Yale University School of Public Health, A Chapter a Day: Association of Book Reading With Longevity. Journal Social Science & Medicine, Sept 2016
15 https://www.sciencedirect.com/science/article/pii/S002839321830321X?via per cent3Dihub
16 https://www.ted.com/talks/lisa_genova_what_you_can_do_to_prevent_alzheimer_s?language=en#t-817227
17 http://n.neurology.org/content/early/2013/11/06/01.wnl.0000436620.33155.a4
18 https://www.sciencedirect.com/science/article/pii/S1053811912006581
19 https://www.ncbi.nlm.nih.gov/pubmed/21463047
20 Carey B. How We Learn, 2014
21 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154531/
22 Interview, UEA, 2018
23 https://www.psyneuen-journal.com/article/S0306-4530(16)30043-9/abstract
24 https://www.frontiersin.org/articles/10.3389/fphys.2018.00626/full
25 https://link.springer.com/article/10.1007/s12671-016-0500-5
26 https://www.ncbi.nlm.nih.gov/pubmed/21035949
27 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062817
28 https://onlinelibrary.wiley.com/doi/abs/10.1111/psyp.13091
29 https://www.ncbi.nlm.nih.gov/pubmed/17655980
30 https://www.ncbi.nlm.nih.gov/pubmed/27983555
31 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923750/
CHAPTER 10
1 https://www.ncbi.nlm.nih.gov/pubmed/24077751
2 https://www.ncbi.nlm.nih.gov/pubmed/25923334
3 https://www.ncbi.nlm.nih.gov/pubmed/12198099
4 https://www.ncbi.nlm.nih.gov/pubmed/24495612
5 Purpose in Life as a Predictor of Mortality across Adulthood
6 Dr Robert Butler et al, HBR May 2014, Craig & Snook, From Purpose to Impact, etc.
7 Psychosomatic Medicine: Journal of Biobehavioral Medicine, Dec. 2015.
8 https://greatergood.berkeley.edu/video/item/how_does_gratitude_affect_health_and_aging
9 https://www.forbes.com/sites/amymorin/2014/11/23/7-scientifically-proven-benefits-of-gratitude-that-will-motivate-you-to-give-thanks-year-round/#79964ac6183c
10 https://www.ncbi.nlm.nih.gov/pubmed/?term=prathik+kini
11 https://www.thecut.com/2016/01/how-expressing-gratitude-change-your-brain.html
12 https://www.health.harvard.edu/blog/in-praise-of-gratitude-201211215561
13 Lisa Feldman Barrett, quoted in The Guardian, April 2017
14 https://www.ncbi.nlm.nih.gov/pubmed/27055911
15 https://www.ncbi.nlm.nih.gov/pubmed/29184526
16 https://www.ncbi.nlm.nih.gov/pubmed/?term=laughter+oxford+dunbar+endorphins+nummenmaa
17 https://www.leeds.ac.uk/news/article/1559/laughter_really_is_the_best_medicine_for_leg_ulcers
18 http://www.mc.vanderbilt.edu:8080/reporter/index.html?ID=4030
19 http://www.the-aps.org/mm/hp/Audiences/Public-Press/Archive/08/10.html
20 https://www.ncbi.nlm.nih.gov/pubmed/19477604
21 https://www.ncbi.nlm.nih.gov/pubmed/16319105
22 https://www.ncbi.nlm.nih.gov/pubmed/29857886
23 https://www.ncbi.nlm.nih.gov/pubmed/20848578
24 http://journals.sagepub.com/doi/abs/10.1177/0956797610363775
25 https://www.psychologytoday.com/us/articles/200011/the-science-laughter
CORNERSTONE FOUR INTRODUCTION
1 A review of the sleep habits of more than 1.3m people showed that risk of death increased by 12 per cent for those who slept for less than six hours a night and by a rather staggering 30 per cent for those who slept more than nine hours. Getting seven to eight hours sleep – and combining it with regular exercise – has been found to significantly reduce the risk of stroke. Sleep deprivation increases the risk of age-related cognitive decline, affects memory and impacts the gut microbiome.
2 We’ve read the books, but unless you’re hugely curious we don’t recommend them. Not if you want to sleep, that is.
CHAPTER 11
1 Durmer J et al, American Academy of Sleep Medicine, June 2018
2 https://ncbi.nlm.nih.gov/pmc/articles/PMC2864873/
3 OK, we’re being a bit facetious here, but experts have previously been very clear that lost sleep can never be reclaimed and that sleep is not a bank we can borrow from and repay later. Not conducive to good sleep!
4 Reported in Sleep Medicine Reviews, Nov 2018
5 Akerstedt T et al, Sleep Mortality and Heredity, Sleep Journal, July 2017
6 https://pubmed.ncbi.nlm.nih.gov/26699485/
7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1522083/
8 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047226/
9 https://www.health.harvard.edu/staying-healthy/blue-light-has-a-dark-side
10 https://www.ncbi.nlm.nih.gov/pubmed/28548897
11 https://www.ncbi.nlm.nih.gov/pubmed/29111816
12 https://www.infona.pl/resource/bwmeta1.element.elsevier-a6f6566f-5464-3b6f-b91c-d0a795b706b7
13 Benveniste H et al, Journal of Neuroscience, 2015
14 https://www.ethz.ch/en/news-and-events/eth-news/news/2018/12/physical-activity-in-the-evening-does-not-cause-sleep-problems.html
15 Science Translational Medicine, Jan. 9, 2019 DOI: 10.1126/scitranslmed.aau6550
16 https://www.ncbi.nlm.nih.gov/pubmed/22702839
17 https://www.sleepfoundation.org/media-center/national-sleep-foundation-poll-finds-exercise-key
18 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216244/
19 https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/presleep-protein-in-casein-supplement-or-wholefood-form-has-no-impact-on-resting-energy-expenditure-or-hunger-in-women/FA272FC2E0B8C9FF85C6DA0918EDFEB7
20 Breus M, The Sleep Doctor’s Diet Plan, Rodale Press 2012
21 Li J et al. intermediate but not extended afternoon naps may preserve cognition in Chinese older adults. Journal Geron A Bio A Med, 2018
22 Campbell SS. Effects of a nap on nigh-time sleep and waking function. J Am Geriatric Soc. 2005
23 Xiaopeng J et al. Behavioural Sleep Medicine, 2018
24 https://academic.oup.com/jcem/article/100/3/E416/2839988
CHAPTER 12
1 https://www.webmd.com/osteoporosis/news/20110607/facial-wrinkles-linked-to-lower-bones-density#1
2 https://www.jidonline.org/article/S0022-202X(16)00453-X/pdf
3 https://www.ncbi.nlm.nih.gov/pubmed/25266053
4 https://www.ncbi.nlm.nih.gov/pubmed/9732303
5 Aguh C et al, Journal of the American Academy of Dermatology, 2016
6 https://www.ncbi.nlm.nih.gov/pubmed/23428658
7 Jenkins D et al, Journal of the American College of Cardiology, May 2018
8 For CVD and stroke only
9 Jacobs D et al, Proc Nutr Soc, 2013 and other earlier studies inc. Shekelle R et al, The Lancet, 1981
10 Rizos E et al, JAMA 2012
11 https://www.ncbi.nlm.nih.gov/pubmed/23958480
12 https://nei.nih.gov/news/pressrelease/cognitive_decline
13 https://www.nature.com/articles/s41424-018-0030-7
14 http://www.pnas.org/content/early/2018/10/18/1810819115
15 Prof. J Mathers, Director, Human Nutrition Research Centre, Newcastle University. Interview
16 Prof JoAnn Manson, Harvard Med School. Interview 2018
17 https://www.ncbi.nlm.nih.gov/pubmed/18375700for instance
18 https://www.nhs.uk/news/medication/zinc-can-cut-length-of-common-cold/
19 Ibid
20 http://newsroom.ucla.edu/releases/ucla-study-suggests-that-iron-247864
21 https://www.alzheimersanddementia.com/article/S1552-5260(17)33876-1/fulltext
22 https://elifesciences.org/articles/32111
23 https://www.nature.com/articles/srep45322
24 http://www.buckinstitute.org/buck-news/new-look-vitamin-d-challenges-current-view-its-benefits
25 Dr Sara Gottfried, Younger: The Breakthrough Programme to reset our Genes and Reverse Aging, 2016. Pg 23
26 http://theconversation.com/vitamin-d-a-pseudo-vitamin-for-a-pseudo-disease-101907
27 Park SK et al. Plasma 25-hydroxyvitamin D concentration and risk of type 2 diabetes and pre-diabetes: 12-year cohort study. PLOS ONE, 2018
28 http://www.dentistrytoday.com/news/industrynews/item/1632-life-expectancy-linked-to-number-of-teeth
29 JAHA, 03/17 DOI: 10.1161/JAHA.116.004518
30 Quoted Carper, 100 Simple Things You Can Do, 2011
31 Chen C, Wu Y, Chang Y. Association between chronic periodontitis and the risk of Alzheimer’s disease: a retrospective, population-based, matched-cohort studyAlzheimer’s Research & Therapy. Published online August 8 2017
32 https://www.ncbi.nlm.nih.gov/pubmed/28154734
33 https://www.ncbi.nlm.nih.gov/pubmed/28154734
34 https://www.ncbi.nlm.nih.gov/pubmed/25109868
35 https://bjo.bmj.com/content/82/8/907
36 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033873/
37 http://www.nrcresearchpress.com/doi/full/10.1139/cjpp-2013-0036#.W2BEFC3MwU0
38 Deutsches Science Museum, Munich
39 https://phys.org/news/2018-08-cancer-treatment-enzymes-boost-immune.html
40 https://www.cell.com/cell/fulltext/S0092-8674(17)30699-2?_returnURL=https per cent3A per cent2F per cent2Flinkinghub.elsevier.com per cent2Fretrieve per cent2Fpii per cent2FS0092867417306992 per cent3Fshowall per cent3Dtrue
41 Cell Host & Microbe Vol. 6, No. 5 446-456, (November 19, 20…
42 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337124/
43 https://www.nature.com/articles/emm201736
44 https://www.ncbi.nlm.nih.gov/pubmed/22429343
45 https://www.ncbi.nlm.nih.gov/pubmed/27023596
CHAPTER 13
1 State of Global Air report, Health Effects Institute, April 2018
2 Quoted in Pollution and non-communicable Disease, The Lancet, March 2018
3 Translational Psychiatry, Jan 2017
4 Living near Major Roads and the Incidence of Dementia, The Lancet, Feb 2017
5 Reported in ScienceMagazine, Jan 2017
6 https://www.theguardian.com/environment/2018/aug/27/air-pollution-causes-huge-reduction-in-intelligence-study-reveals
7 BBC documentary, Fighting for Air, Jan 2018
8 Effects of gaseous and solid constituents of air pollution on endothelial function. European Heart Journal Aug 2018
9 Ljubimova, Scientific Reports, 2018
10 American Thoracic Society. ‘Mediterranean diet may blunt air pollution’s ill health effects.’ ScienceDaily. ScienceDaily, 21 May 2018
11 https://www.ewg.org/childrenshealth/glyphosateincereal/
12 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972442/
13 Quoted in Carper J, 100 Simple Things you can do to Prevent Alzheimer’s
14 Environ Toxicol. 2018 Jan 23
15 Annual Review Pharmacol Toxicol. 2014;54:141-64
16 https://www.fasebj.org/doi/10.1096/fj.201700759RR
17 Environ Health Prev Med 2018 Jan 27;23(1):3
18 https://ehp.niehs.nih.gov/doi/10.1289/ehp.1408197
19 Studies quoted by Alzheimer’s Society
20 JAMA Internal Medicine, Jan 2015
21 BMJ2018;361:k1722
22 Association Between Proton Pump Inhibitor Use and Cognitive Function in Women.Gastroenterology, 2017; DOI: 10.1053/j.gastro.2017.06.061
CHAPTER 14
1 Professor of Dementia Research and Director of Ageing, UEA and Norwich Medical School, Interview, UEA, 2018
